Thursday, July 18, 2013

Testosterone Replacement Therapy and Prostate Cancer Risk? Come again??

Let's diverge for a couple of posts before we discuss various needle gauges and pain thresholds.  

Recently, I have heard more "rumorous" circulating stories of potential prostate cancer risk and TRT therapy.  One particular gentleman had low T levels 64 years old. His urologist started giving him a version of TRT, although I am unaware of the testosterone compounds used by the urologist.  Moreover, I would hardly recommend a urologist to treat low testosterone and if truly fine tweaking of the male hormone levels were necessary, an endocrinologist should have been consulted. Only they truly have the specialized knowledge necessary to understand the complex interactions of testosterone (T4, free circulating and unbound testosterone), estrogen, IGF-1, liver proteins, etc., that all should be considered when balancing the boundaries of each hormone. 

The gentleman apparently had months worth of 1 injection per month month and his T levels came back to normal. This is rather abnormal in itself due to the fact that TRT therapy interferes with the body's natural testosterone producing and regulating mechanism, often shrinking the testes and leading to months of post TRT therapy before T levels may resume to healthy and normal levels and often require the use of a type of "testosterone" reviver, such as hCG so that the testes never truly shut down and the patient can avoid the "crash" often associated with sudden TRT stoppage. 

The gentleman already had a good and reasonable sex drive for his age, but, a rather hectic physical sports regime of hobbies had him thinking he could use a boost in hormonal energy.  However, after 6 months of injections, he felt he was not experiencing any real physical improvements. 

After reading other blogs or non-refereed articles, such as this one, although being decidedly anti-TRT and reading about side effects and deciding TRT was a relatively new medical treatment and he wouldn't be a "test subject" anymore for an unproven and yet to be scientifically studied therapy.  Despite being very wrong in his decision about there being junk science behind the treatment and no studies in place demonstrating the medical benefits of TRT he stopped TRT and  claimed to 'feel just fine without it' and although his T levels went back to quite low levels he felt justified in not increasing the risk of prostate cancer or something else. He continues to feel justified in his not using TRT and paying for it down the road in what he seems to feel is the eternal chase after more muscle and increased sex drive in the here and now. In some aspects I doubt he has even been on TRT since he talks about large needles but no pain.  No doctor, including myself would use a large gauge needle for the actual injection of testosterone in an oily substance deep into muscle tissue.  

Moreover, both low and high testosterone have about equal chances of causing prostate cancer if you were prone to it.  When the male body experiences low T their estrogen levels can become out of sync and become quite high, and is often demonstrated through excess body fat, mammary tissue, irritability, etc., and there are numerous studies that show Low-T/High-E levels have a higher impact on prostate growth than high T with normal E levels.


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